pH‐sensitive K + current in glial cells of the retrotrapezoid nucleus (RTN)
نویسندگان
چکیده
منابع مشابه
Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus.
Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (i.e., chemoreceptors) regulate breathing in response to changes in tissue pH. A region of the brain stem called the retrotrapezoid nucleus (RTN) is thought to be an important site of chemoreception (23), and recent evidence suggests that RTN chemoreception involves two interrelated mechanisms: H+-mediated activation of p...
متن کاملHIGHLIGHTED TOPIC Central CO2 Chemoreception in Cardiorespiratory Control Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus
Mulkey DK, Wenker IC, Kréneisz O. Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid nucleus. J Appl Physiol 108: 1433–1439, 2010. First published January 21, 2010; doi:10.1152/japplphysiol.01240.2009.—Central chemoreception is the mechanism by which CO2/pH-sensitive neurons (i.e., chemoreceptors) regulate breathing in response to changes in tissue pH. A re...
متن کاملGABAergic pump cells of solitary tract nucleus innervate retrotrapezoid nucleus chemoreceptors.
The retrotrapezoid nucleus (RTN) contains central respiratory chemoreceptors that are inhibited by activation of slowly adapting pulmonary stretch receptors (SARs). Here we examine whether RTN inhibition by lung inflation could be mediated by a direct projection from SAR second-order neurons (pump cells). Pump cells (n = 56 neurons, 13 rats) were recorded in the nucleus of solitary tract (NTS) ...
متن کاملIntrinsic pH-Sensitivity of Cells in the Retrotrapezoid Nucleus: Possible Role of Glia in Respiratory Drive
An increase in carbon dioxide (CO2) and protons (H+) are the primary signals for breathing. Cells that sense changes in CO2/H+ levels and increase breathing accordingly are located in a region of the caudal medulla oblongata called the retrotrapezoid nucleus (RTN). Specifically, select RTN neurons are intrinsically pH sensitive and send excitatory projections to the respiratory rhythm generator...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.621.11